Mekong Cruises from Siem Reap
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10 best Mekong river cruises from Siem Reap
Compiled by
MelissaSiem Reap travel expert at TourRadar
- Riches of the Mekong 2026
- Wonders of Cambodia, Vietnam & the Mekong 2025-2026|2026-2027
- The Mekong in a different way - Between adventure and must-seesites (port-to-port cruise) (from Siem Reap to Ho Chi Minh City)
- From the Temples of Angkor to the Mekong Delta & The Imperial Cities (port-to-port cruise) (including Cu Chi)
- The Mekong in a different way - Between adventure and must-see sites (port-to-port cruise) (10 destinations)
- Meandering along the Mekong 2025|2026 - 10 Days (from Siem Reap to Ho Chi Minh City)
- From the Angkor Temples to the Mekong Delta (port-to-port cruise) (22 destinations)
- From Siem Reap to the Mekong Delta (port-to-port cruise)
- Spiritual Cambodia and The Mekong Siem Reap → Ho Chi Minh City (2025)
- Majestic Mekong Cruising Siem Reap → Ho Chi Minh City (2025)
The AmaDara awaits in Kampong Cham for a 7-night Mekong cruise from Siem Reap. The route winds through traditional villages, ancient temples, and vibrant markets to Ho Chi Minh City, with notable stops at Phnom Penh, Tan Chau, and Sa Dec.
Duration 8 days Destinations Siem Reap, Kampong Cham, Angkor Ban, Silk Island, Hanchey, Oudong, Kampong Tralach, Phnom Penh, Ho Chi Minh City, Tan ChauSee all destinations Age Range up to 90 year olds Ship AmaDara River Mekong Operator AmaWaterways From
- US$3,049
After Angkor temple visits in Siem Reap, the Emerald Harmony sets sail from Prek K'dam. The 7-night Mekong adventure flows through Phnom Penh, Tan Chau, and Sa Dec, ending in Ho Chi Minh City, covering approximately 850 kilometers.
Duration 13 days Destinations Siem Reap, Angkor Wat, Kampong Tralach, Oudong, Phnom Penh, Tan Chau, My An Hung, Sa Dec, Cai Be, My ThoSee all destinations Age Range up to 90 year olds River Mekong Operator Emerald Cruises From $10,150
46% Off- US$5,468You save $4,682
This 9-day Mekong route leads from Siem Reap's Lotus Blanc Hotel to Ho Chi Minh City. Stops include Phnom Penh, Chau Doc, Sa Dec, Udong Hill and Kampong Tralach. A 5-6 hour coach connects Koh Chen to Siem Reap. Approx. $280 per day.
Duration 9 days Destinations Siem Reap, Koh Chen, Kampong Tralach, Phnom Penh, Chau Doc, Sa Dec, Cai Be, My Tho, Ho Chi Minh City Age Range up to 99 year olds River Mekong Operator CroisiEurope River Cruises From
46% Off- US$1,891
From Siem Reap's Angkor temples, a remarkable 850km route spans Cambodia and Vietnam. The itinerary crosses Tonle Sap Lake to Phnom Penh, follows the Mekong Delta via Chau Doc and Sa Dec, reaching Hanoi through Ho Chi Minh City. This 17-day tour encompasses 18 destinations.
Duration 17 days Destinations Siem Reap, Angkor Wat, Koh Chen, Kampong Tralach, Kampong Chhnang, Phnom Penh, Chau Doc, Sa Dec, Vinh Long, Cai BeSee all destinations Age Range up to 99 year olds Ships RV IndochineRV Indochine II River Mekong Operator CroisiEurope River Cruises From
46% Off- US$5,672
The intimate Toum Tiou 2 cruise ship carries passengers from Siem Reap's Lotus Blanc Hotel on a 5-6 hour sail to Koh Chen. The route crosses Cambodia's Tonle Sap Lake to Phnom Penh, enters Vietnam at Vinh Xuong border, and visits the Mekong Delta's Chau Doc, Sa Dec, and My Tho before Ho Chi Minh City.
Duration 9 days Destinations Siem Reap, Koh Chen, Kampong Chhnang, Kampong Tralach, Phnom Penh, Chau Doc, Sa Dec, Cai Be, My Tho, Ho Chi Minh City Age Range up to 99 year olds River Mekong Operator CroisiEurope River Cruises From
46% Off- US$1,896
Your Mekong adventure starts in Siem Reap, continuing to Kampong Cham to board Scenic Spirit. The cruise meanders through Cambodia and Vietnam, featuring Wat Hanchey, Phnom Penh, and rural villages, concluding with a 90-minute transfer to Ho Chi Minh City.
Duration 10 days Destinations Siem Reap, Hanchey, Kampong Cham, Angkor Ban, Silk Island, Phnom Penh, Tan Chau, Sa Dec, Cai Be, Ho Chi Minh City Age Range up to 99 year olds Ship Scenic Spirit River Mekong Operator Scenic Luxury Cruises & Tours From $10,490
54% Off- US$4,858You save $5,632
From the Angkor Temples to the Mekong Delta (port-to-port cruise) (22 destinations)
1 Review by TourRadar travelers“Accommodation was very good although our room at the back was a little noisy. Very well organized and excellent tour manager.”
Susan, traveled in February 2019
Angkor temple visits in Siem Reap precede a 2,700-mile Mekong cruise aboard RV Indochine II. The route crosses Tonle Sap Lake to Phnom Penh's Royal Palace, ventures to Vietnam's Chau Doc and Sa Dec, ending in Ho Chi Minh City. This 11-day tour covers 11 destinations.
Duration 11 days Destinations Siem Reap, Tonle Sap Lake, Kampong Tralach, Koh Chen, Phnom Penh, Chau Doc, Sa Dec, Vinh Long, Cai Be, My ThoSee all destinations Age Range up to 99 year olds Ships RV IndochineRV Indochine II RV Lan Diep River Mekong Operator CroisiEurope River Cruises From
54% Off- US$3,266
The RV Indochine carries travelers from Siem Reap's Lotus Blanc Hotel 2,700 miles south through Kampong Tralach's rice fields and Phnom Penh's Royal Palace. The route includes Chau Doc, Sa Dec, and My Tho before reaching Ho Chi Minh City's historic Cholon district, with port-to-city transfers included.
Duration 9 days Destinations Siem Reap, Tonle Sap Lake, Kampong Tralach, Koh Chen, Phnom Penh, Chau Doc, Sa Dec, Vinh Long, Cai Be, My ThoSee all destinations Age Range up to 99 year olds Ships RV IndochineRV Indochine II RV Lan Diep River Mekong Operator CroisiEurope River Cruises From
54% Off- US$2,046
After staying at Sofitel Angkor Phokeethra Resort in Siem Reap, the Mekong Serenity awaits in Kampong Cham. The 315-mile voyage passes through Phnom Penh, Tan Chau, and Sa Dec, culminating in Ho Chi Minh City.
Duration 11 days Destinations Siem Reap, Kampong Cham, Koh Pen, Angkor Ban, Phnom Penh, Oudong, Koh Chen, Tan Chau, Sa Dec, Cai BeSee all destinations Age Range up to 99 year olds River Mekong Operator APT From
54% Off- US$3,982
A tuk-tuk ride through Koh Pen island starts this Siem Reap adventure before boarding RV Apsara. The route encompasses 11 destinations including Angkor Ban village, Phnom Penh's Royal Palace, and Sa Dec's floating markets, finishing in Ho Chi Minh City.
Duration 8 days Destinations Siem Reap, Kampong Cham, Angkor Ban, Phnom Penh, Oudong, Koh Chen, Tan Chau, Sa Dec, Cai Be, My ThoSee all destinations Age Range up to 99 year olds River Mekong Operator Travel Marvel From
54% Off- US$1,803
What people love about Mekong Cruises from Siem Reap
- From the Angkor Temples to the Mekong Delta (port-to-port cruise) (22 destinations)
We had a great time. Accommodation was very good although our room at the back was a little noisy due to being near the generator and engine room which I would not recommend ( maybe a discounted price should be offered ). Very well organized and excellent tour manager. Always something on the itinerary even whilst the boat was sailing eg cookery demos, serviette folding, fruit carving, talks, films. I think the cruise could be shortened by a couple of days as a lot of the things we saw were very repetitive ,especially the pagodas! We were the only English guests on board which at times was a little difficult but on the plus side we had our own personal English speaking guides (3 in total at different parts of the cruise) which was fantastic. Chan Seng in Cambodia has to have a special mention for his fantastic knowledge and understanding of English.The food both on board and at restaurants on land was excellent my only complaint was that the drinks were not included in the package which for the price we paid I think they should have been, as most cruises do, ( only a soft drink or a beer were included per person per meal). Overall I would recommend this cruise as we had a lovely time.