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Best of South America with Amazon Cruise Santiago → Iquitos (2026)

22 days
•
From Santiago to Iquitos
4.1
24 traveler reviews
Best of South America with Amazon Cruise Santiago → Iquitos (2026) - APT
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Plan your adventure:
  • Explorer
  • Family
  • Wildlife
  • Group
  • Fully Guided
  • Sightseeing
  • Historical
Operator
APT
Group Tour
Join a group and forge lifelong friendships
Fully Guided
An experienced guide will be with you for the entire tour
Guided in English
Group Size 1 - 200
Age range 8 to 99

Places You’ll See

  • Valparaiso
    Valparaiso
  • Buenos Aires
    Buenos Aires
  • Iguazu Falls
    Iguazu Falls
  • Rio de Janeiro
    Rio de Janeiro
  • Lima
    Lima
  • Cusco
    Cusco
  • Sacred Valley
    Sacred Valley
  • Moray
    Moray
  • Machu Picchu
    Machu Picchu
Image of a map showing the route of the tour

Highlights

  • Ride the funicular in Valparaíso for stunning views
  • Explore Buenos Aires with a tango and tapas night
  • Stay at the only hotel inside Iguazú National Park
  • Journey to Machu Picchu on the Inca Rail First Class
  • Meet a Shaman and explore the Amazon by kayak

Itinerary

Expand All
  1. Introduction
  1. Day 1 Arrive Santiago
  2. Day 2 Santiago, Valparaíso
  3. Day 3 Santiago
  4. Day 4 Santiago, Buenos Aires
  5. Day 5 Buenos Aires
  6. Day 6 Buenos Aires
  7. Day 7 Buenos Aires, Iguazú Falls
  8. Day 8 Iguazú Falls
  9. Day 9 Iguazú Falls, Rio de Janeiro
  10. Day 10 Rio de Janeiro
  11. Day 11 Rio de Janeiro
  12. Day 12 Rio de Janeiro, Lima
  13. Day 13 Lima
  14. Day 14 Lima, Sacred Valley
  15. Day 15 Sacred Valley, Maras, Moray
  16. Day 16 Sacred Valley, Machu Picchu
  17. Day 17 Machu Picchu, Cusco
  18. Day 18 Cusco
  19. Day 19 Iquitos, Amazon Cruise
  20. Day 20 Amazon Cruise
  21. Day 21 Amazon Cruise
  22. Day 22 Depart Iquitos
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What's Included

Expand All
  • Accommodation
  • Flights
  • Guide
  • Meals
  • Additional Services
  • Transport

What's Not Included

  • Insurance
  • Optional
  • Additional Services

Where You'll Stay

All accommodations are subject to change

  • Santiago

    Hotel
    Days 1, 2, 3

  • Buenos Aires

    Hotel
    Days 4, 5, 6

  • Iguazú Falls

    Hotel
    Days 7, 8

  • Copacabana Palace

    Hotel
    Days 9, 10, 11

  • Country Club Lima Hotel

    Hotel
    Days 12, 13

  • Explora Sacred Valley

    Hotel
    Days 14, 15

  • Sumaq Machu Picchu Hotel

    Hotel
    day 16

  • Cusco

    Hotel
    Days 17, 18

  • Amazon River

    Hotel
    Days 19, 20, 21

Operated by

APT

Number of tours

254

Age Range

8 to 99 years old

Response time

within 2 days

Response rate

91%

A family-owned company since its conception in the 1920s. APT had its...

Read more

Your Peace of Mind Options

Cancellation Policy

A transparent overview of applicable fees.

Travel Insurance

Be covered for any unforseen circumstances.

APT Ship

  • Delfin III
    Delfin III
    The 169-foot-long, Delfin III has been tailor made to suit its environment, while maintaining its integrity as a true luxury river cruise… Read more
    Built
    2015 (refurbished: 2017)
    Guests
    44
    Crew
    29
    Length
    51.5 m / 169 ft
    Suites
    22
    Beam
    12 m / 39 ft
    Cruising Speed
    10 kn / 19 kph / 12 mph
    Draft
    5ft / 1.5m
    Staterooms / SuitesDeck PlansDining

Reviews About This Operator

Dates & Availability

22 days
Best of South America with Amazon Cruise Santiago → Iquitos (2026)
From Santiago to Iquitos

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    To protect your payment and ensure your booking will be processed in United States, never transfer or communicate outside of the TourRadar website or app.

More benefits
Select a departure month
  • Upcoming departures
  • March 2026
  • July 2026
  • October 2026
Select The Travel Month

Select transport

Upcoming departures
  • From Tuesday
    17 Mar, 2026
    To Tuesday
    7 Apr, 2026
    Not available in your region
  • From Tuesday
    21 Jul, 2026
    To Tuesday
    11 Aug, 2026
    Not available in your region
  • From Tuesday
    6 Oct, 2026
    To Tuesday
    27 Oct, 2026
    Not available in your region
  • From Tuesday
    20 Oct, 2026
    To Tuesday
    10 Nov, 2026
    Not available in your region
  • 3 Other Unavailable Departures
Can’t find the answer to your question?
Reach out to the experts at APT with your enquiry, they usually respond within 2 days.

Good to Know

Tour ID: 307089

  • Currencies
    $
    Argentine Peso
    Argentina
    R$
    Brazilian Real
    Brazil
    $
    Chilean Peso
    Chile
    S/.
    Sol
    Peru
  • Plugs & Adapters

    As a traveler from USA, Canada, England, South Africa you will need an adaptor for types I, L. As a traveler from Australia, New Zealand you will need an adaptor for type L.

    Type I
    Argentina
    Type L
    Chile
  • Vaccines
    • These are only indications, so please visit your doctor before you travel to be 100% sure.
    • Typhoid - Recommended for Argentina, Brazil, Chile and Peru. Ideally 2 weeks before travel.
    • Hepatitis A - Recommended for Argentina, Brazil, Chile and Peru. Ideally 2 weeks before travel.
    • Hepatitis B - Recommended for Argentina, Brazil, Chile and Peru. Ideally 2 months before travel.
    • Rabies - Recommended for Argentina, Chile and Peru. Ideally 1 month before travel.
    • Yellow fever - Recommended for Argentina, Brazil and Peru. Ideally 10 days before travel.
    • Tuberculosis - Recommended for Brazil and Peru. Ideally 3 months before travel.
  • Visa
    • Unfortunately we cannot offer you a visa application service. Whether you need a visa or not depends on your nationality and where you wish to travel. Assuming your home country does not have a visa agreement with the country you're planning to visit, you will need to apply for a visa in advance of your scheduled departure.
    • Here is an indication for which countries you might need a visa. Please contact the local embassy for help applying for visas to these places.
  • Payment information
    • For any tour departing before July 27th, 2025 a full payment is necessary. For tours departing after July 27th, 2025, a minimum payment of $750 is required to confirm your booking with APT. The final payment will be automatically charged to your credit card on the designated due date. The final payment of the remaining balance is required at least 120 days prior to the departure date of your tour. TourRadar never charges you a booking fee and will charge you in the stated currency.
    • The following cards are accepted for "APT" tours: Visa, Maestro, Mastercard, American Express or PayPal. TourRadar does NOT charge you an extra fee for using any of these payment methods.
  • Cancellation Policy
  • Accessibility
    Some tours are not suitable for mobility-restricted traveler, however, some operators may be able to accommodate special requests. For any enquiries, you can contact our customer support team, who are ready and waiting to help you.
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