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Best of South America with Amazon & Galápagos Cruises Santiago → Guayaquil (2026)

29 days
•
From Santiago to Guayaquil
4.1
24 traveler reviews
Best of South America with Amazon & Galápagos Cruises Santiago → Guayaquil (2026) - APT
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Plan your adventure:
  • Explorer
  • Family
  • Wildlife
  • Group
  • Fully Guided
  • Ocean Cruise
  • Sightseeing
  • Historical
Operator
APT
Group Tour
Join a group and forge lifelong friendships
Fully Guided
An experienced guide will be with you for the entire tour
Guided in English
Group Size 1 - 200
Age range 8 to 99

Places You’ll See

  • Valparaiso
    Valparaiso
  • Buenos Aires
    Buenos Aires
  • Iguazu Falls
    Iguazu Falls
  • Rio de Janeiro
    Rio de Janeiro
  • Lima
    Lima
  • Sacred Valley
    Sacred Valley
  • Moray
    Moray
  • Machu Picchu
    Machu Picchu
  • Cusco
    Cusco
  • Guayaquil
    Guayaquil
  • Santa Cruz Island
    Santa Cruz Island
  • Rabida Island
    Rabida Island
  • San Cristóbal Island
    San Cristóbal Island
Image of a map showing the route of the tour

Highlights

  • Ride the funicular in Valparaíso for stunning views
  • Explore Buenos Aires with a tango show and tapas
  • Witness the majestic Iguazú Falls from various angles
  • Discover Machu Picchu with a local guide
  • Navigate the Amazon River and meet local communities

Itinerary

Expand All
  1. Introduction
  1. Day 1 Arrive Santiago
  2. Day 2 Santiago, Valparaíso
  3. Day 3 Santiago
  4. Day 4 Santiago, Buenos Aires
  5. Day 5 Buenos Aires
  6. Day 6 Buenos Aires
  7. Day 7 Buenos Aires, Iguazú Falls
  8. Day 8 Iguazú Falls
  9. Day 9 Iguazú Falls, Rio de Janeiro
  10. Day 10 Rio de Janeiro
  11. Day 11 Rio de Janeiro
  12. Day 12 Rio de Janeiro, Lima
  13. Day 13 Lima
  14. Day 14 Lima, Sacred Valley
  15. Day 15 Sacred Valley, Maras, Moray
  16. Day 16 Sacred Valley, Machu Picchu
  17. Day 17 Machu Picchu, Cusco
  18. Day 18 Iquitos, Amazon Cruise
  19. Day 19 Amazon Cruise
  20. Day 20 Amazon Cruise
  21. Day 21 Iquitos, Lima
  22. Day 22 Lima, Guayaquil
  23. Day 23 Galápagos Islands
  24. Day 24 Galápagos Islands
  25. Day 25 Galápagos Islands
  26. Day 26 Galápagos Islands
  27. Day 27 Galápagos Islands, Guayaquil
  28. Day 28 Depart Guayaquil
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What's Included

Expand All
  • Accommodation
  • Flights
  • Guide
  • Meals
  • Additional Services
  • Transport

What's Not Included

  • Insurance
  • Optional
  • Additional Services

Where You'll Stay

All accommodations are subject to change

  • Santiago

    Hotel
    Days 1, 2, 3

  • Buenos Aires

    Hotel
    Days 4, 5, 6

  • Iguazú Falls

    Hotel
    Days 7, 8

  • Copacabana Palace

    Hotel
    Days 9, 10, 11

  • Country Club Lima Hotel

    Hotel
    Days 12, 13, 21

  • Explora Sacred Valley

    Hotel
    Days 14, 15

  • Sumaq Machu Picchu Hotel

    Hotel
    day 16

  • Cusco

    Hotel
    Days 17, 18

  • Amazon River

    Hotel
    Days 18, 19, 20

  • Hotel del Parque

    Hotel
    Days 22, 27

  • Galápagos Islands

    Hotel
    day 23

Operated by

APT

Number of tours

254

Age Range

8 to 99 years old

Response time

within 2 days

Response rate

90%

A family-owned company since its conception in the 1920s. APT had its...

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Your Peace of Mind Options

Cancellation Policy

A transparent overview of applicable fees.

Travel Insurance

Be covered for any unforseen circumstances.

Reviews About This Operator

Dates & Availability

29 days
Best of South America with Amazon & Galápagos Cruises Santiago → Guayaquil (2026)
From Santiago to Guayaquil

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    To protect your payment and ensure your booking will be processed in United States, never transfer or communicate outside of the TourRadar website or app.

More benefits
Select a departure month
  • Upcoming departures
  • April 2026
  • June 2026
  • August 2026
  • September 2026
Select The Travel Month

Upcoming departures
  • From Tuesday
    14 Apr, 2026
    To Tuesday
    12 May, 2026
    Not available in your region
  • From Tuesday
    9 Jun, 2026
    To Tuesday
    7 Jul, 2026
    Not available in your region
  • From Tuesday
    4 Aug, 2026
    To Tuesday
    1 Sep, 2026
    Not available in your region
  • From Tuesday
    29 Sep, 2026
    To Tuesday
    27 Oct, 2026
    Not available in your region
  • 3 Other Unavailable Departures
Can’t find the answer to your question?
Reach out to the experts at APT with your enquiry, they usually respond within 2 days.

Good to Know

Tour ID: 307090

  • Currencies
    $
    Argentine Peso
    Argentina
    R$
    Brazilian Real
    Brazil
    $
    Chilean Peso
    Chile
    $
    US Dollar
    Ecuador
    S/.
    Sol
    Peru
  • Plugs & Adapters

    As a traveler from USA, Canada, England, South Africa you will need an adaptor for types I, L. As a traveler from Australia, New Zealand you will need an adaptor for type L.

    Type I
    Argentina
    Type L
    Chile
  • Vaccines
    • These are only indications, so please visit your doctor before you travel to be 100% sure.
    • Typhoid - Recommended for Argentina, Brazil, Chile, Ecuador and Peru. Ideally 2 weeks before travel.
    • Hepatitis A - Recommended for Argentina, Brazil, Chile, Ecuador and Peru. Ideally 2 weeks before travel.
    • Hepatitis B - Recommended for Argentina, Brazil, Chile, Ecuador and Peru. Ideally 2 months before travel.
    • Rabies - Recommended for Argentina, Chile, Ecuador and Peru. Ideally 1 month before travel.
    • Yellow fever - Recommended for Argentina, Brazil, Ecuador and Peru. Ideally 10 days before travel.
    • Tuberculosis - Recommended for Brazil, Ecuador and Peru. Ideally 3 months before travel.
  • Visa
    • Unfortunately we cannot offer you a visa application service. Whether you need a visa or not depends on your nationality and where you wish to travel. Assuming your home country does not have a visa agreement with the country you're planning to visit, you will need to apply for a visa in advance of your scheduled departure.
    • Here is an indication for which countries you might need a visa. Please contact the local embassy for help applying for visas to these places.
  • Payment information
    • For any tour departing before July 28th, 2025 a full payment is necessary. For tours departing after July 28th, 2025, a minimum payment of $750 is required to confirm your booking with APT. The final payment will be automatically charged to your credit card on the designated due date. The final payment of the remaining balance is required at least 120 days prior to the departure date of your tour. TourRadar never charges you a booking fee and will charge you in the stated currency.
    • The following cards are accepted for "APT" tours: Visa, Maestro, Mastercard, American Express or PayPal. TourRadar does NOT charge you an extra fee for using any of these payment methods.
  • Cancellation Policy
  • Accessibility
    Some tours are not suitable for mobility-restricted traveler, however, some operators may be able to accommodate special requests. For any enquiries, you can contact our customer support team, who are ready and waiting to help you.
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